A synthetic, chloride-selective channel that alters chloride transport in epithelial cells
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چکیده
منابع مشابه
A Synthetic Chloride Channel Restores Chloride Conductance in Human Cystic Fibrosis Epithelial Cells
Mutations in the gene-encoding cystic fibrosis transmembrane conductance regulator (CFTR) cause defective transepithelial transport of chloride (Cl(-)) ions and fluid, thereby becoming responsible for the onset of cystic fibrosis (CF). One strategy to reduce the pathophysiology associated with CF is to increase Cl(-) transport through alternative pathways. In this paper, we demonstrate that a s...
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We investigated Cl(-) transport pathways in the apical and basolateral membranes of rabbit esophageal epithelial cells (EEC) using conventional and ion-selective microelectrodes. Intact sections of esophageal epithelium were mounted serosal or luminal side up in a modified Ussing chamber, where transepithelial potential difference and transepithelial resistance could be determined. Microelectro...
متن کاملChloride and potassium channel function in alveolar epithelial cells.
Electrolyte transport across the adult alveolar epithelium plays an important role in maintaining a thin fluid layer along the apical surface of the alveolus that facilitates gas exchange across the epithelium. Most of the work published on the transport properties of alveolar epithelial cells has focused on the mechanisms and regulation of Na(+) transport and, in particular, the role of amilor...
متن کاملEpithelial Chloride Channel Development of lnhibitory Ligands
I N T R O D U C T I O N Chloride channels are present in the plasma membranes o f epithelia (Frizzell et al., 1981), nerve (Hamill et al., 1983), and muscle (Blatz and Magleby, 1985), as well as in intraceilular membranes such as Golgi apparatus (Glickman et al., Address reprint requests to Dr. Qais AI-Awqati, Depts. of Medicine and Physiology, College of Physicians and Surgeons, Columbia Unive...
متن کاملSynthetic chloride transporters with the binding mode observed in a ClC chloride channel.
A series of synthetic molecules bearing the same hydrogen bonding mode observed in StClC were prepared and their transport ability of chloride ion across a lipid membrane was systematically optimized.
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ژورنال
عنوان ژورنال: Chem. Commun.
سال: 2006
ISSN: 1359-7345,1364-548X
DOI: 10.1039/b513940f